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KMID : 0370920040210020237
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Yeungnam Univercity Journal of Medicine
2004 Volume.21 No. 2 p.237 ~ p.241
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A Case of Complete Remission of Hairy Cell Leukemia by 2-Chlorodeoxyadenosine
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김용길/Kim YG
이상진/김민경/이경희/현명수/조희순/Lee SJ/Kim MK/Lee KH/Hyun MS/Cho HS
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Abstract
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Hairy cell leukemia (HCL) is an uncommon chronic B-cell lymphoproliferative disorder that is characterized by cytopenia, splenomegaly, and mononuclear cells displaying cytoplasmic projections. We experienced a case of hairy cell leukemia that developed in a 38-year-old man. He showed marked splenomegaly without palpable lymphoadenopathy. A complete blood cell count revealed leukopenia (3300/microliter with 63% of lymphocyte) and the peripheral blood smear showed abnormal lymphoid cells with cytoplasmic projections. The bone marrow smear revealed abnormal lymphocytes and severe myelofibrosis. Tartrate-resistant acid phosphatase reactivity was strongly positive in the hairy cells. The immunophenotyping results of lymphoid cells were CD5(-), CD10(-), CD19(+), CD25(+), CD103(+), CD20(+), lambda(+). The patient was treated with 2-Chlorodeoxyadenosine at a daily dose of 0.1mg/Kg by a continuous intravenous infusion for 7 days. The patient achieved complete remission.
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